What is aging?
That question has been central to philosophy and medicine for ages and remains at the frontier of medicine today. There are several inconsistent answers, each correct. Experts agree, however that “biological aging” is a highly complex process with many different events and pathways likely to be involved. The most popular mechanisms by which aging occurs include:
- Cell senescence and telomere shortening,
- Environmental and oxidative stress,
- The influence of nutrient availability on the biological pathways that control cell division and metabolism.
The last mechanism includes imbalance of brain energetics which is a main hypothesis in our approach to the diagnosis and treatment of AD.